Denis Furling Selected Research

Myotonic Dystrophy (Dystrophia Myotonica)

1/2022	Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats.
12/2021	CRISPR gene editing in pluripotent stem cells reveals the function of MBNL proteins during human in vitro myogenesis.
3/2020	miR-7 Restores Phenotypes in Myotonic Dystrophy Muscle Cells by Repressing Hyperactivated Autophagy.
1/2020	A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1.
11/2019	Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice.
4/2019	Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1.
1/2019	Pluripotent Stem Cell-Based Drug Screening Reveals Cardiac Glycosides as Modulators of Myotonic Dystrophy Type 1.
1/2019	Genome Editing of Expanded CTG Repeats within the Human DMPK Gene Reduces Nuclear RNA Foci in the Muscle of DM1 Mice.
1/2018	Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells.
1/2018	rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.

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Denis Furling Research Topics

Disease

33	Myotonic Dystrophy (Dystrophia Myotonica) 01/2022 - 09/2002
5	Neuromuscular Diseases (Neuromuscular Disease) 12/2021 - 08/2014
4	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2020 - 07/2009
3	Muscular Diseases (Myopathy) 11/2019 - 08/2014
3	Muscular Dystrophies (Muscular Dystrophy) 06/2011 - 07/2004
2	Muscle Weakness 01/2020 - 11/2018
1	Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital) 12/2020
1	Fatigue 01/2020
1	Ventricular Tachycardia 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 11/2019
1	Myotonia 02/2017
1	Ataxia (Dyssynergia) 01/2017
1	Infections 06/2009
1	Hypertrophy 02/2007
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 09/2002
1	Congenital Structural Myopathies (Centronuclear Myopathy) 09/2002

Drug/Important Bio-Agent (IBA)

13	RNA (Ribonucleic Acid)IBA 01/2022 - 08/2009
4	3' Untranslated Regions (3' UTR)IBA 03/2020 - 01/2012
4	DystrophinIBA 01/2020 - 07/2009
4	Myotonin-Protein KinaseIBA 01/2018 - 03/2003
3	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2009
3	Messenger RNA (mRNA)IBA 04/2019 - 09/2002
3	Protein Kinases (Protein Kinase)IBA 02/2017 - 03/2003
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2022 - 06/2011
2	OligonucleotidesIBA 11/2019 - 08/2009
2	Pharmaceutical PreparationsIBA 11/2019 - 01/2019
2	Nuclear RNAIBA 01/2017 - 04/2012
1	Synaptotagmin IIIBA 12/2020
1	CRISPR-Cas Systems Guide RNAIBA 01/2020
1	DesminIBA 01/2020
1	Complementary DNA (cDNA)IBA 01/2020
1	Antisense OligonucleotidesIBA 11/2019
1	Peptides (Polypeptides)IBA 11/2019
1	Circular RNAIBA 04/2019
1	Cardiac GlycosidesIBA 01/2019
1	AICA ribonucleotide (ZMP)IBA 02/2017
1	Mechanistic Target of Rapamycin Complex 1IBA 02/2017
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 01/2017
1	Metformin (Glucophage)FDA LinkGeneric 11/2015
1	RNA Splicing FactorsIBA 08/2014
1	Nuclear Proteins (Protein, Nuclear)IBA 08/2014
1	CELF1 ProteinIBA 03/2014
1	Transcription Factors (Transcription Factor)IBA 12/2013
1	Carrier Proteins (Binding Protein)IBA 12/2013
1	Dinoprostone (PGE2)FDA Link 01/2012
1	Protein Isoforms (Isoforms)IBA 01/2011
1	Antiviral Agents (Antivirals)IBA 06/2009
1	Ribavirin (Virazole)FDA LinkGeneric 06/2009
1	InterferonsIBA 06/2009
1	PotassiumIBA 01/2009
1	Interleukin-13IBA 02/2007
1	Myosins (Myosin)IBA 02/2007
1	Insulin (Novolin)FDA Link 02/2007
1	Insulin-Like Growth Factor I (IGF-1)IBA 02/2007
1	NFATC Transcription FactorsIBA 02/2007
1	phosphatidylinositol 3-phosphateIBA 09/2002
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 09/2002
1	myotubularinIBA 09/2002

Therapy/Procedure

2	Therapeutics 01/2020 - 01/2016
1	Defibrillators (Defibrillator) 01/2020
1	Intramuscular Injections 01/2019
1	Cell- and Tissue-Based Therapy (Cell Therapy) 07/2004